Stabilized Liposomes transdermal patch for loaded antioxidants skin therapy

Abstract

As the largest organ in the body, skin acts a protective barrier insulating other organs from physical, chemical or biological damage. Skin aging triggered by sun’s ultraviolet rays, and pollution decrease its protective barrier and it’s physiological functional properties. The research hunt is on by cosmetic industry and dermatologist for effective therapeutic technologies to slow and reverse skin aging. Some modern skin antiaging therapy include the radiofrequency technology that work on the basis of thermal energy application onto the skin, believed to induce dermal and epidermal remodeling, which triggers regeneration.1,2 This is an expensive, public inaccessible therapeutic technology, and as such an economical approach remain the use of anti-aging skin care products with functional compounds called antioxidants, which protects the skin from free radical oxidative processes that induce skin aging. Numerous antioxidants exist, —e.g. retinol, algae oil, and lecithin, — however there remains a challenge for optimal transdermal delivery of these compounds the epidermis to afford effective skin protection. In addition, antioxidants are environmentally unstable, and lose their potency with exposure. As such, approach to mitigate both the instability and as a delivery vehicle is the use of liposome technology. Liposome is a (nano) or microsphere with an aqueous center pocket (houses the anti-aging agent) and a lipid exterior, a dual structure that affords skin penetration.3,4

As a proof concept, we have developed polyhydroxylated fatty acid (polyol) liposome and used it to encapsulate a model antiaging agent. The polylol liposomes was compared with lecithin based liposomes for controlled release on the anti-aging agent. Towards a fabrication of a dermatologist usable device, we have demonstrated a prototype voltage responsive biobased transdermal patch impregnated with antioxidant loaded liposomes, with controlled release of the antiaging agent triggered by disruption of the liposomes by a mild voltage application. Our presentation, will showcase the developed prototype.

Reference

1.       Deirdre, C.; Laura, L.; Nazanin, Saedi. Semin Cutan Med Surg. 2017. 36. 138-147.
2.       Krista, B.; Anderw, D.; Neil, S. J Cosmet Dermatol. 2018. 17. 61-65.
3.       Makoto, T.; Dai, K.; Yonathan, A.; Kensaku, T.; Koji, W. Journal of Oleo Science. 2009, 12, 643-650.
4.       Sala, M.; Diab, R.; Elaissari, A.; Fessi, A. Lipid Nanocarriers as Skin Drug Delivery Systems: Properties, Mechanisms of Skin Interactions and Medical Applications. Int J Pharm. 2018 Jan 15;535(1-2):1-17.

*Indicates presenter