Effectiveness of Contact Lens Cleaning Solutions on the Disruption of Biofilms Formed by Different Microorganisms

Abstract

My objective is to examine biofilm formation of Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans on contact lenses and to test the effectiveness of different contact lens cleaning solutions to remove or disinfect the biofilms. These particular microorganisms are commonly found as pathogens in ocular tissue. Given the tendency for biofilms to form on contact lenses especially after the lenses are removed from the eye and are saturated with nutrient-rich lipoproteins that “feed” contaminating microorganisms, it is important to undertake simple hygienic measures to ensure biofilm formation is prevented. After biofilms were experimentally formed on daily contact lenses, the lenses were subjected to four different treatment solutions that included a Biotrue™ multipurpose cleaner, an Opti-free™ multipurpose cleaner, a Clear Care™ hydrogen peroxide-based solution or tap water. A second experiment was conducted where the same treatments were tested on rigid gas permeable lenses (RGPs), monthly and extended wear contact lenses. These different solutions were chosen because they have different active ingredients. I anticipate these experiments will provide important information to help inform contact lens users how to best maintain their contact lens cleaning regimens and protect their eyes from infections.