Synthesis and Characterization of Schiff Base Ligands Derived from Amino Acids

  • Kevin Chambers Concordia University of Edmonton
  • Anita Balogh Concordia University of Edmonton
  • James Titah* Concordia University of Edmonton


Schiff base ligands and their metal complexes have been shown to exhibit important biological activities in biological systems and in the pharmaceutical industry (anti-tumor, anti-cancer, anti-malaria, anti-diabetic, etc). Significant research in this area is ongoing and a lot of complexes have been synthesized with promising biological and/or catalytic activities [1-4]. This project is the preliminary step to synthesizing metal complexes with Schiff Base ligands derived from amino acids for use in biological systems and/or catalysis. In this project, we have synthesized Schiff Base ligands from salicylaldehyde, benzaldehyde, and 4-dimethylnitrobenzaldehyde, with the following amino acids: alanine, histidine, leucine, valine, phenylalanine, and serine. The general names of the ligands are N-salicylidene, N-benzalidene, and N-dimethylnitrobenzalidene amino acids, respectively. Characterization of the ligands have been done using the following techniques; UV-visible spectroscopy, 1H NMR spectroscopy, IR spectroscopy, melting/decomposition point, and solubility tests. The results will be presented in the poster. 


  1. H. L. Singh and J. Singh, Int. J. of Inorg. Chem., 2013, (vol 2013), pp1-10

  2. M. Alias, H. Kassum and C. Shakir, JAAUBAS, 2014, (vol. 15), pp28-34

  3. Rathore et al., Eur. J. Chem. 2010, pp. S566–S572 7(S1)

  4. E. Yousif et al., Arabian, J. Chem., 2013, pp1-5

*Indicates faculty mentor.

Poster Abstracts